Evaluation of Simplified Childhood Vaccination Schedules Incorporating Pneumococcal Vaccines

Serotype-specific immunity and association with pneumococcal carriage following 3 1, 3 0 and 2 1 schedules of 10-valent pneumococcal conjugate vaccine.

Darren Suryawijaya Ong, Zheng Quan Toh, Beth Temple, Cattram Duong Nguyen, Thanh V Phan, Vo Thi Trang Dai, Anne Balloch, Rachel Ann Higgins, Belinda Daniela Ortika, Jemima Beissbarth, Kathryn Bright, Kien Vientrung, Leena Spry, Monica Larissa Nation, Nhung Vu Pham Hong, Nguyen Trong Toan, Pham Thi Hoan, Yin Bun Cheung, Heidi Smith-Vaughan, Catherine Satzke

2026-03-12

BACKGROUND: Correlates of protection for pneumococcal carriage, a precursor for invasive pneumococcal disease, are not well define..

Relationship between IL-17_A and pneumococcal carriage in children aged under two years: data from a randomised controlled trial in Vietnam

ZQ Toh, YY Ma, B Temple, J Anderson, HH Far, TV Phan, VTT Dai, TN Huu, NT Toan, K Bright, ML Nation, BD Ortika, C Nguyen, H Smith-Vaughan, C Satzke, K Mulholland, PV Licciardi

2026-02-01

Objective: Pneumococcal carriage is a prerequisite for invasive pneumococcal disease (IPD). Interleukin (IL)-17 A and IL-17 A-prod..

Streptococcus pneumoniae nasopharyngeal carriage in Vietnamese children during the first five years of life: a post hoc analysis

F Marincek, B Temple, S Manna, HP Tran, VT Trang Dai, K Bright, UY Doan, VT Tuong Le, PL Tran, C Nguyen, T Van Phan, HN Loc Thuy, J Hinds, A Wee-Hee, L Spry, C Pell, J Beissbarth, B Ortika, H Smith-Vaughan, HN Tran

2026-02-01

Background: Streptococcus pneumoniae (the pneumococcus) is one of the main causes of childhood mortality. Understanding pneumococc..

Effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in Vietnamese infants: results from a randomised controlled trial

H Smith-Vaughan, B Temple, VT Trang Dai, PT Hoan, HN Loc Thuy, TV Phan, K Bright, NT Toan, DY Uyen, CD Nguyen, J Beissbarth, BD Ortika, ML Nation, EM Dunne, J Hinds, J Lai, C Satzke, TN Huu, K Mulholland

2023-03-01

Background: WHO recommends a three-dose infant pneumococcal conjugate vaccine (PCV) schedule administered as a two-dose primary se..

Immunogenicity and impact on nasopharyngeal carriage of a single dose of PCV10 given to vietnamese children at 18 months of age

RA Higgins, B Temple, VTT Dai, TV Phan, NT Toan, L Spry, ZQ Toh, ML Nation, BD Ortika, DY Uyen, YB Cheung, CD Nguyen, K Bright, J Hinds, A Balloch, H Smith-Vaughan, TN Huu, K Mulholland, C Satzke, PV Licciardi

2021-11-01

Background: This study investigated the immunogenicity and impact on nasopharyngeal carriage of a single dose of PCV10 given to 18..

Immunogenicity of alternative ten-valent pneumococcal conjugate vaccine schedules in infants in Ho Chi Minh City, Vietnam: results from a single-blind, parallel-group, open-label, randomised, controlled trial

PV Licciardi, B Temple, VTT Dai, NT Toan, D Uyen, CD Nguyen, TV Phan, K Bright, RA Marimla, A Balloch, TN Huu, K Mulholland

2021-10-01

Background: Data are scarce from low-income and middle-income countries (LMICs) to support the choice of vaccination schedule for ..

Effect of a 2 1 schedule of ten-valent versus 13-valent pneumococcal conjugate vaccine on pneumococcal carriage: Results from a randomised controlled trial in Vietnam

B Temple, ML Nation, VTT Dai, J Beissbarth, K Bright, EM Dunne, J Hinds, PT Hoan, J Lai, CD Nguyen, BD Ortika, TV Phan, HNL Thuy, NT Toan, DY Uyen, C Satzke, H Smith-Vaughan, TN Huu, K Mulholland

2021-04-15

Background: Pneumococcal conjugate vaccines (PCVs) generate herd protection by reducing nasopharyngeal (NP) carriage. Two PCVs, PC..

Brief communication: immunogenicity of measles vaccine when co-administered with 10-valent pneumococcal conjugate vaccine

ZQ Toh, B Temple, TN Huu, VTT Dai, NT Toan, DY Uyen, K Bright, LAH Do, EK Mulholland, PV Licciardi

2020-12-01

This brief communication describes the findings from a randomised controlled trial in Vietnam that co-administration of measles va..

Hospital surveillance predicts community pneumococcal antibiotic resistance in Vietnam

VTT Dai, J Beissbarth, PV Thanh, PT Hoan, HNL Thuy, T N. Huu, K Bright, C Satzke, EK Mulholland, B Temple, HC Smith-Vaughan

2020-10-01

Background: In Vietnam, Streptococcus pneumoniae is a leading cause of disease, including meningitis. Antibiotics are available wi..

Brief communication: immunogenicity of measles vaccine when co-administered with 10-valent pneumococcal conjugate vaccine.

Zheng Quan Toh, Beth Temple, Tran Ngoc Huu, Vo Thi Trang Dai, Nguyen Trong Toan, Doan Y Uyen, Kathryn Bright, Lien Anh Ha Do, E Kim Mulholland, Paul V Licciardi

2020-08-18

This brief communication describes the findings from a randomised controlled trial in Vietnam that co-administration of measles va..

Immunogenicity and reactogenicity of ten-valent versus 13-valent pneumococcal conjugate vaccines among infants in Ho Chi Minh City, Vietnam: a randomised controlled trial

B Temple, NT Toan, VTT Dai, K Bright, PV Licciardi, RA Marimla, CD Nguyen, DY Uyen, A Balloch, TN Huu, EK Mulholland

2019-05-01

Background: Few data are available to support the choice between the two currently available pneumococcal conjugate vaccines (PCVs..

Evaluation of different infant vaccination schedules incorporating pneumococcal vaccination (The Vietnam Pneumococcal Project): Protocol of a randomised controlled trial

B Temple, NT Toan, DY Uyen, A Balloch, K Bright, YB Cheung, P Licciardi, CD Nguyen, NTM Phuong, C Satzke, H Smith-Vaughan, TQH Vu, TN Huu, EK Mulholland

2018-06-01

Introduction WHO recommends the use of pneumococcal conjugate vaccine (PCV) as a priority. However, there are many countries yet t..